Article
Association of UGT1A1 Gly71Arg with urine urobilinogen.
Nagoya journal of medical science - 1 Feb 2011
Kataoka Ryuji, Kimata Akiko, Yamamoto Kanami, Hirosawa Naoko, Ueyama Jun, Kondo Takaaki, Okada Rieko, Kawai Sayo, Hishida Asahi, Naito Mariko, Morita Emi, Wakai Kenji, Hamajima Nobuyuki
Abstract excerpt
Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile. The conjugated form is metabolized into the unconjugated form, and then into urobilinogen by bacteria in the intestine. Unconjugated bilirubin and urobilinogen are absorbed into the blood stream. The kidney filtrates conjugated bilurubin and urobilinogen into urine. Accordingly, the...
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