Article
UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China.
BMC pediatrics - 1 Jun 2021
Yang Hui, Lin Fen, Chen Zi-Kai, Zhang Lin, Xu Jia-Xin, Wu Yong-Hao, Gu Jing-Ying, Ma Yu-Bin, Li Jian-Dong, Yang Li-Ye
Abstract excerpt
BACKGROUND: Neonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form. METHOD: A retrospective study was conducted to review clinical information of ABO hemolysis neonates (ABO HDN) admitted to the Department of Neonatology, referred for...
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