Article
Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma.
Cancer epidemiology - 1 Dec 2011
Mandelcorn-Monson Rochelle, Marrett Loraine, Kricker Anne, Armstrong Bruce K, Orlow Irene, Goumas Chris, Paine Susan, Rosso Stefano, Thomas Nancy, Millikan Robert C, Pole Jason D, Cotignola Javier, Rosen Cheryl, Kanetsky Peter A, Lee-Taylor Julia, Begg Colin B, Berwick Marianne
Abstract excerpt
BACKGROUND: Sunlight exposure increases risk of melanoma. Sunlight also potentiates cutaneous synthesis of vitamin D, which can inhibit melanoma cell growth and promote apoptosis. Vitamin D effects are mediated through the vitamin D receptor (VDR). We hypothesized that genetic variation in VDR affects the relationship of sun exposure to risk of a further melanoma in people who have already had one. METHODS: We...
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