The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.

doi:10.1111/pcmr.12653

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Article

The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.

Pigment cell & melanoma research - 1 Mar 2018

Orlow Irene, Shi Yang, Kanetsky Peter A, Thomas Nancy E, Luo Li, Corrales-Guerrero Sergio, Cust Anne E, Sacchetto Lidia, Zanetti Roberto, Rosso Stefano, Armstrong Bruce K, Dwyer Terence, Venn Alison, Gallagher Richard P, Gruber Stephen B, Marrett Loraine D, Anton-Culver Hoda, Busam Klaus, Begg Colin B, Berwick Marianne

Abstract excerpt

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05)....

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PMID: 28990310
DOI: 10.1111/pcmr.12653
PMCID: PMC5809306

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Source receipt: pubmed, retrieved 6 Sept 2026.

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