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Article

Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.

The Journal of investigative dermatology - 1 Feb 2007

Li Chunying, Liu Zhensheng, Zhang Zhengdong, Strom Sara S, Gershenwald Jeffrey E, Prieto Victor G, Lee Jeffrey E, Ross Merrick I, Mansfield Paul F, Cormier Janice N, Duvic Madeleine, Grimm Elizabeth A, Wei Qingyi

Abstract excerpt

Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM. In a hospital-based case-control study of 602 non-Hispanic white CM patients and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16990805
DOI: 10.1038/sj.jid.5700544

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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