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Article

Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.

DNA and cell biology - 1 Sept 2011

Gazquez Irene, Lopez-Escamez Jose A, Moreno Antonia, Campbell Colleen A, Meyer Nicole C, Carey John P, Minor Lloyd B, Gantz Bruce J, Hansen Marlan R, Della Santina Charles C, Aran Ismael, Soto-Varela Andres, Santos Sofia, Batuecas Angel, Perez-Garrigues Herminio, Lopez-Nevot Alicia, Smith Richard J H, Lopez-Nevot Miguel A

Abstract excerpt

Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are associated with MD, we genotyped three functional variants of NOS1 (rs41279104, rs2682826, and a...

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Identifiers

PMID: 21612410
DOI: 10.1089/dna.2011.1259

Genes

NOS1

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Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.PMID 21612410Read ↗

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