Article
Impact of TAS2R38 polymorphisms on nasal nitric oxide and Pseudomonas infections in primary ciliary dyskinesia: relation to genotype.
Thorax - 16 Oct 2024
Pifferi Massimo, Boner Attilio, Maj Debora, Michelucci Angela, Donzelli Gabriele, Cangiotti Angela M, Guazzo Raffaella, Bertolucci Giulia, Bertini Veronica, Doccioli Chiara, Piazza Michele, Valetto Angelo, Caligo Maria Adelaide, Peroni Diego, Bush Andrew
Abstract excerpt
OBJECTIVE: Primary ciliary dyskinesia (PCD) severity has been related to genotype and levels of nasal nitric oxide (nNO). The most common TAS2R38 haplotypes (PAV/PAV, PAV/AVI, AVI/AVI) encoding the bitter taste receptor can affect nNO levels and thus could play a role in the susceptibility to respiratory infections. We assessed the impact of these polymorphisms on nNO production and Pseudomonas aeruginosa (P.a.)...
Topics
- Humans
- Male
- Nitric Oxide
- Female
- Prospective Studies
- Pseudomonas Infections
- Receptors, G-Protein-Coupled
- Genotype
- Child
- Adolescent