Article
A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD.
Molecular psychiatry - 1 Jul 2012
Jain M, Vélez J I, Acosta M T, Palacio L G, Balog J, Roessler E, Pineda D, Londoño A C, Palacio J D, Arbelaez A, Lopera F, Elia J, Hakonarson H, Seitz C, Freitag C M, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch K-P, Swanson J, Castellanos F X, Bailey-Wilson J E, Arcos-Burgos M, Muenke M
Abstract excerpt
In previous studies of a genetic isolate, we identified significant linkage of attention deficit hyperactivity disorder (ADHD) to 4q, 5q, 8q, 11q and 17p. The existence of unique large size families linked to multiple regions, and the fact that these families came from an isolated population, we hypothesized that two-locus interaction contributions to ADHD were plausible. Several analytical models converged to...
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