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Article

A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome.

Translational psychiatry - 5 Jul 2011

Acosta M T, Vélez J I, Bustamante M L, Balog J Z, Arcos-Burgos M, Muenke M

Abstract excerpt

The severity of attention-deficit/hyperactivity disorder (ADHD) symptoms is a major predictor of long-term ADHD outcome. To investigate if two-locus interactions might predict ADHD severity, we studied a sample of 1341 individuals from families clustering ADHD, using the Vanderbilt Assessment Scale for Parents. Latent class cluster analysis was used to construct symptom profiles and classify ADHD severity. Single...

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Share to Attention Deficit Disorder with Hyperactivity
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Genetic Loci

Share to Receptors, Dopamine D2

Share to Receptors, G-Protein-Coupled

Share to Receptors, Peptide

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 22832519
DOI: 10.1038/tp.2011.14
PMCID: PMC3309519

Genes

DRD2
NCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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