Article
Ser756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2.
The Biochemical journal - 1 Aug 2011
Lim Jenson, Hotchin Neil A, Caron Emmanuelle
Abstract excerpt
During αMβ2-mediated phagocytosis, the small GTPase Rap1 activates the β2 integrin by binding to a region between residues 732 and 761. Using COS-7 cells transfected with αMβ2, we show that αMβ2 activation by the phorbol ester PMA involves Ser(756) of β2. This residue is critical for the local positioning of talin and biochemically interacts with Rap1. Using the CaM (calmodulin) antagonist W7, we found Rap1...
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