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Article

Diversity in the Regulation of Autophagy and Mitophagy: Lessons from Parkinson's Disease

1 Jan 2011

Abstract excerpt

Selective mitochondrial degradation through autophagy (mitophagy) has emerged as an important homeostatic mechanism in a variety of organisms and contexts. Complete clearance of mitochondria can be observed during normal maturation of certain mammalian cell types, and during certain forms of neuronal cell death. In recent years, autophagy dysregulation has been implicated in toxin-injured dopaminergic neurons as...

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PMID: 21603187
DOI: 10.4061/2011/789431

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