Article
Age of inoculum strongly influences persister frequency and can mask effects of mutations implicated in altered persistence.
Journal of bacteriology - 1 Jul 2011
Luidalepp Hannes, Jõers Arvi, Kaldalu Niilo, Tenson Tanel
Abstract excerpt
The majority of cells transferred from stationary-phase culture into fresh medium resume growth quickly, while a few remain in a nongrowing state for longer. These temporarily nonproliferating bacteria are tolerant of several bactericidal antibiotics and constitute a main source of persisters. Several genes have been shown to influence the frequency of persisters in Escherichia coli, although the exact mechanism...
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