Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects.

doi:10.1186/1476-511X-11-9

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Article

Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects.

Lipids in health and disease - 13 Jan 2012

Wu Dong-Feng, Yin Rui-Xing, Aung Lynn Htet Htet, Li Qing, Yan Ting-Ting, Zeng Xiao-Na, Huang Ke-Ke, Huang Ping, Wu Jin-Zhen, Pan Shang-Ling

Abstract excerpt

BACKGROUND: Acyl-CoA:cholesterol acyltransferase (ACAT) is a key enzyme in cellular cholesterol homeostasis and in atherosclerosis. The cellular cholesterol efflux correlated with serum high-density lipoprotein cholesterol (HDL-C) concentrations has shown to be impaired in hyperlipidemic mice. The present study was carried out to clarify the association of ACAT-1 rs1044925 single nucleotide polymorphism (SNP) and...

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PMID: 22243772
DOI: 10.1186/1476-511X-11-9
PMCID: PMC3271972

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