Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach.

Abstract excerpt

BACKGROUND: Phenotype-driven forward genetic experiments are powerful approaches for linking phenotypes to genomic elements but they still involve a laborious positional cloning process. Although sequencing of complete genomes now becomes available, discriminating causal mutations from the enormous amounts of background variation remains a major challenge. METHOD: To improve this, we developed a universal...

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