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Article

Anaplastic thyroid cancer: outcome and the mutation/expression profiles of potential targets.

Pathology oncology research : POR - 1 Jul 2015

Wu Hao, Sun Yue, Ye Huihui, Yang Shi, Lee Stephanie L, de las Morenas Antonio

Abstract excerpt

Anaplastic thyroid cancer (ATC) is a rare but aggressive malignancy of the thyroid. No effective treatment modalities are currently available. Targeted therapy against protein kinases showed promising results in preclinical studies. Our goal was to assess the mutational status of potential therapeutic targets, as well as the biomarker for immunotherapy in the clinical context. Using allele specific PCR, Sanger...

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Source

Identifiers

PMID: 25588542
DOI: 10.1007/s12253-014-9876-5

Genes

BRAF
EGFR
KIT
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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