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Article

Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate.

The Journal of biological chemistry - 15 Jul 2011

Zaiss Anne K, Lawrence Roger, Elashoff David, Esko Jeffrey D, Herschman Harvey R

Abstract excerpt

Serum coagulation factor X (FX) is proposed to play a major role in adenovirus tropism, promoting transduction by bridging the virus to cell-surface heparan sulfate proteoglycans (HSPGs). Both murine FX and human FX increased transduction by Ad.CMVfLuc, an adenovirus vector, in murine hepatocyte-like cells and human hepatocarcinoma cells. In contrast, only hFX increased transduction of several non-hepatic cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21596747
DOI: 10.1074/jbc.M111.241562
PMCID: PMC3137028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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