Article
Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.
Human molecular genetics - 15 Dec 2012
Tyrrell Jessica, Huikari Ville, Christie Jennifer T, Cavadino Alana, Bakker Rachel, Brion Marie-Jo A, Geller Frank, Paternoster Lavinia, Myhre Ronny, Potter Catherine, Johnson Paul C D, Ebrahim Shah, Feenstra Bjarke, Hartikainen Anna-Liisa, Hattersley Andrew T, Hofman Albert, Kaakinen Marika, Lowe Lynn P, Magnus Per, McConnachie Alex, Melbye Mads, Ng Jane W Y, Nohr Ellen A, Power Chris, Ring Susan M, Sebert Sylvain P, Sengpiel Verena, Taal H Rob, Watt Graham C M, Sattar Naveed, Relton Caroline L, Jacobsson Bo, Frayling Timothy M, Sørensen Thorkild I A, Murray Jeffrey C, Lawlor Debbie A, Pennell Craig E, Jaddoe Vincent W V, Hypponen Elina, Lowe William L, Jarvelin Marjo-Riitta, Davey Smith George, Freathy Rachel M
Abstract excerpt
Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We...
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