Article
The short arm of chromosome 11 likely is involved in the regulation of the human papillomavirus type 16 early enhancer-promoter and in the suppression of the transforming activity of the viral DNA.
Virology - 1 May 1990
Smits P H, Smits H L, Jebbink M F, ter Schegget J
Abstract excerpt
Loci on the short arm of chromosome 11 between 11p11 and 11p15 likely are involved directly or indirectly in the regulation of the HPV-16 enhancer-promoter strength and this may contribute to the control of the level of viral early gene expression. Transient expression assays have shown that the HPV-16 enhancer-promoter functions much stronger in fibroblasts in which this region of chromosome 11 (del-11 cells) is...
Topics
- Cells, Cultured
- Chromosomes, Human, Pair 11
- DNA, Viral
- Enhancer Elements, Genetic
- Fibroblasts
- Humans
- Mutation
- Papillomaviridae
- Promoter Regions, Genetic
- RNA, Viral