Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line.

doi:10.1074/jbc.270.41.24321

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line.

The Journal of biological chemistry - 13 Oct 1995

Gallego M I, Lazo P A

Abstract excerpt

In human cervical carcinomas papillomavirus DNA is frequently integrated in the cell genome. We have cloned the integration site of human papillomavirus-18 DNA in human chromosome region 12q13-15 present in the SW756 cervical carcinoma cell line. Viral DNA is broken from nucleotides 2643 to 3418 in the E1 and E2 open reading frames, resulting in a deletion of 775 bases of viral DNA. Cloning and sequence analysis...

Topics

Alleles
Base Sequence
Cell Line
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 12
Cloning, Molecular
DNA, Viral
Female
Genetic Markers
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Papillomaviridae

Recombination, Genetic

Restriction Mapping

Tumor Cells, Cultured

Uterine Cervical Neoplasms

Virus Integration

Source

Open in PubMed

Identifiers

PMID: 7592643
DOI: 10.1074/jbc.270.41.24321

Genes

CDK4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7592643-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line.PMID 7592643Read ↗

Genomic cloning and characterization of the nonoccupied allele corresponding to the integration site of human papillomavirus type 16 DNA in the cervical cancer cell line SiHa.Semantic proximity Read ↗

The Majority of Viral-Cellular Fusion Transcripts in Cervical Carcinomas Cotranscribe Cellular Sequences of Known or Predicted GenesSemantic proximity Read ↗

The integration of HPV-18 DNA in cervical carcinoma.Semantic proximity Read ↗

Mapping and analysis of HPV16 integration sites in a head and neck cancer cell lineSemantic proximity Read ↗

Frequent genomic structural alterations at HPV insertion sites in cervical carcinomaSemantic proximity Read ↗

Single copy heterozygote integration of HPV 33 in chromosomal band 5p14 is found in an epithelial cell clone with selective growth advantage.Semantic proximity Read ↗

Analysis of integrated human papillomavirus type 16 DNA in cervical cancers: amplification of viral sequences together with cellular flanking sequencesSemantic proximity Read ↗

Physical State of HPV16 and Chromosomal Mapping of the Integrated Form in Cervical CarcinomasSemantic proximity Read ↗

Interstitial deletion of 11q13 sequences in HeLa cells.Semantic proximity Read ↗

Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomesSemantic proximity Read ↗

Deletion of chromosome 11p13-11p15.5 sequences in invasive human ovarian cancer is a subclonal progression factor.Semantic proximity Read ↗

Allelotyping of all chromosomal arms in invasive cervical cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.