Article
Transcriptional activation of human papillomavirus 16 by nuclear factor I, AP1, steroid receptors and a possibly novel transcription factor, PVF: a model for the composition of genital papillomavirus enhancers.
Nucleic acids research - 11 Feb 1990
Chong T, Chan W K, Bernard H U
Abstract excerpt
Human papillomavirus 16 (HPV-16), which is involved in genital carcinogenesis, contains an enhancer of transcription that is activated by cellular factors rather than by the viral E2 proteins. The activity resides on a 232 bp segment with 5 binding sites for nuclear factor 1 (NF1), 2 for AP1, and 1 for steroid receptors. Deletions and point mutations show that the constitutive enhancer and the steroid response...
Topics
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cloning, Molecular
- DNA, Viral
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Glucocorticoids
- Molecular Sequence Data
- Mutation