Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus.

doi:10.1016/0042-6822(90)90443-u

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Article

Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus.

Virology - 1 Apr 1990

Kumura K, Ibusuki K, Minamishima Y

Abstract excerpt

A temperature-sensitive (ts) mutant of murine cytomegalovirus, ts21, lacks pathogenicity for suckling mice. Revertants (rev21) of ts21 which could replicate at nonpermissive temperature remained attenuated, suggesting the presence of a temperature-independent factor(s) for the attenuation. Coinfe...

Topics

Animals
Animals, Suckling
Cytomegalovirus
Cytomegalovirus Infections
Disease Models, Animal
Mice
Mutation
Phenotype
Temperature
Virulence
Virus Replication

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