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Article

Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial.

PLoS medicine - 1 Jan 2012

Lockman Shahin, Hughes Michael, Sawe Fred, Zheng Yu, McIntyre James, Chipato Tsungai, Asmelash Aida, Rassool Mohammed, Kimaiyo Sylvester, Shaffer Douglas, Hosseinipour Mina, Mohapi Lerato, Ssali Francis, Chibowa Margret, Amod Farida, Halvas Elias, Hogg Evelyn, Alston-Smith Beverly, Smith Laura, Schooley Robert, Mellors John, Currier Judith

Abstract excerpt

BACKGROUND: Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based initial ART. METHODS AND FINDINGS: In seven African countries (Botswana, Kenya, Malawi, South Africa, Uganda, Zambia, and Zimbabwe), 500 antiretroviral-naïve HIV-infected women with...

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Source

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Identifiers

PMID: 22719231
DOI: 10.1371/journal.pmed.1001236
PMCID: PMC3373629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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