Article
Genetic elements involved in Tn21 site-specific integration, a novel mechanism for the dissemination of antibiotic resistance genes.
The EMBO journal - 1 Apr 1990
Martinez E, de la Cruz F
Abstract excerpt
Transposon Tn21 codes for a site-specific integration system, which is probably a novel recombination mechanism, responsible for the acquisition of resistance genes in this widespread family of transposons. Using insertion and deletion mutagenesis we have identified the genetic loci of the various recombination hot-spots (RHS) and of the gene product (the integrase) that catalyses the reaction. The site of...
Topics
- Base Sequence
- Chromosome Deletion
- DNA Nucleotidyltransferases
- DNA Transposable Elements
- Drug Resistance, Microbial
- Escherichia coli
- Genes, Bacterial
- Integrases
- Molecular Sequence Data
- Mutation
- R Factors