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Article

Integron cassette insertion: a recombination process involving a folded single strand substrate.

The EMBO journal - 21 Dec 2005

Bouvier Marie, Demarre Gaëlle, Mazel Didier

Abstract excerpt

Integrons play a major role in the dissemination of antibiotic resistance genes among Gram-negative pathogens. Integron gene cassettes form circular intermediates carrying a recombination site, attC, and insert into an integron platform at a second site, attI, in a reaction catalyzed by an integron-specific integrase IntI. The IntI1 integron integrase preferentially binds to the 'bottom strand' of single-stranded...

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Identifiers

PMID: 16341091
DOI: 10.1038/sj.emboj.7600898
PMCID: PMC1356339

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