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Article

Enhanced detection of BRAF-mutants by pre-PCR cleavage of wild-type sequences revealed circulating melanoma cells heterogeneity.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2011

Fusi Alberto, Berdel Rebecca, Havemann Swantje, Nonnenmacher Anika, Keilholz Ulrich

Abstract excerpt

PURPOSE: Characterisation of circulating melanoma cells (CMC) for BRAF status can provide a strategy for non-invasive serial genotype monitoring in patients receiving BRAF inhibitors. We aimed to establish a method for BRAF mutation analysis at CMC level and we applied it in a cohort of CMC-positive patients. METHODS: We established a sensitive method for detection of BRAF mutations at codon 600 in whole blood...

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Source

Identifiers

PMID: 21570823
DOI: 10.1016/j.ejca.2011.04.013

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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