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BRAF mutation analysis in circulating free tumor DNA of melanoma patients treated with BRAF inhibitors.

Melanoma research - 1 Dec 2015

Gonzalez-Cao Maria, Mayo-de-Las-Casas Clara, Molina-Vila Miguel A, De Mattos-Arruda Leticia, Muñoz-Couselo Eva, Manzano Jose L, Cortes Javier, Berros Jose P, Drozdowskyj Ana, Sanmamed Miguel, Gonzalez Alvaro, Alvarez Carlos, Viteri Santiago, Karachaliou Niki, Martin Algarra Salvador, Bertran-Alamillo Jordi, Jordana-Ariza Nuria, Rosell Rafael

Abstract excerpt

BRAFV600E is a unique molecular marker for metastatic melanoma, being the most frequent somatic point mutation in this malignancy. Detection of BRAFV600E in blood could have prognostic and predictive value and could be useful for monitoring response to BRAF-targeted therapy. We developed a rapid, sensitive method for the detection and quantification of BRAFV600E in circulating free DNA (cfDNA) isolated from...

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Identifiers

PMID: 26366702
DOI: 10.1097/CMR.0000000000000187

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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