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Article

Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase.

Free radical biology & medicine - 1 Jul 2011

Lin Xinghua, Yang Hong, Zhou LiChun, Guo ZhongMao

Abstract excerpt

Overexpression of catalase has been shown to accelerate benzo(a)pyrene (BaP) detoxification in mouse aortic endothelial cells (MAECs). NAD(P)H:quinone oxidoreductase-1 (NQO1) is an enzyme that catalyzes BaP-quinone detoxification. Aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor-2 (Nrf2) are transcription factors that control NQO1 expression. Here, we investigated the effects of...

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Source

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Identifiers

PMID: 21569840
DOI: 10.1016/j.freeradbiomed.2011.04.020
PMCID: PMC3109219

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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