Article
Overexpression of wild-type and nuclear-targeted catalase modulates resistance to oxidative stress but does not alter spontaneous mutant frequencies at APRT.
Mutation research - 3 Apr 2000
Schriner S E, Smith A C, Dang N H, Fukuchi K, Martin G M
Abstract excerpt
Animal cells generate hydrogen peroxide as a byproduct of energy metabolism. In the presence of reduced metals H(2)O(2) can decompose to a highly reactive hydroxyl radical that attacks essentially all organic molecules, including DNA. We wished to determine if overexpression of catalase and/or the targeting of the enzyme to the nucleus could protect cells from oxidative stress and reduce the frequency of...
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