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Article

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children.

Malaria journal - 14 May 2011

Mombo-Ngoma Ghyslain, Oyakhirome Sunny, Ord Rosalynn, Gabor Julian J, Greutélaers Katja C, Profanter Katharina, Greutélaers Benedikt, Kurth Florian, Lell Bertrand, Kun Jürgen F J, Issifou Saadou, Roper Cally, Kremsner Peter G, Grobusch Martin P

Abstract excerpt

BACKGROUND: Drug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP). METHODS: The study assessed the frequency of SP resistance-conferring polymorphisms in Plasmodium falciparum-positive samples from two clinical studies in Lambaréné. Their role on treatment...

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Identifiers

PMID: 21569596
DOI: 10.1186/1475-2875-10-123
PMCID: PMC3112455

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Source receipt: pubmed, retrieved 7 Sept 2026.

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