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The potential of cold-shock promoters for the expression of recombinant proteins in microbes and mammalian cells

1 Dec 2022

Abstract excerpt

BACKGROUND: Low-temperature expression of recombinant proteins may be advantageous to support their proper folding and preserve bioactivity. The generation of expression vectors regulated under cold conditions can improve the expression of some target proteins that are difficult to express in different expression systems. The cspA encodes the major cold-shock protein from Escherichia coli (CspA). The promoter of...

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PMID: 36580173
DOI: 10.1186/s43141-022-00455-9

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