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Tamoxifen metabolites treatment promotes ERα+ transition to triple negative phenotype in vitro, effects of LDL in chemoresistance.

Bioscience reports - 28 Aug 2024

Muñoz-Ayala Andrea, Chimal-Vega Brenda, Serafín-Higuera Nicolás, Galindo-Hernández Octavio, Ramírez-Rosales Gladys, Córdova-Guerrero Iván, Gómez-Lucas Luis Fernando, García-González Victor

Abstract excerpt

OBJECTIVE: Estrogen receptor-positive (ER+) breast cancer represents about 80% of cases, tamoxifen is the election neoadjuvant chemotherapy. However, a large percentage of patients develop chemoresistance, compromising recovery. Clinical evidence suggests that high plasmatic levels of low-density lipoproteins (LDL) could promote cancer progression. The present study analyzed the effect of LDL on the primary...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39034849
DOI: 10.1042/BSR20240444
PMCID: PMC11301570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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