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Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain

4 Sept 2017

Abstract excerpt

Strong breakthrough pain is one of the most disabling symptoms of cancer since it affects up to 90% of cancer patients and is often refractory to treatments. Alteration in gene expression is a known mechanism of cancer pain in which microRNAs (miRNAs), a class of non-coding regulatory RNAs, play a crucial role. Here, in a mouse model of cancer pain, we show that miR-124 is down-regulated in the spinal cord, the...

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PMID: 28887457
DOI: 10.1038/s41598-017-10224-1

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