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Article

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

PloS one - 29 Apr 2011

Bhat Rakesh K, Ellestad Kristofor K, Wheatley B Matt, Warren Rene, Holt Robert A, Power Christopher

Abstract excerpt

BACKGROUND: The glycoprotein, Syncytin-1, is encoded by a human endogenous retrovirus (HERV)-W env gene and is capable of inducing neuroinflammation. The specific allele(s) responsible for Syncytin-1 expression in the brain is uncertain. Herein, HERV-W env diversity together with Syncytin-1 abundance and host immune gene profiles were examined in the nervous system using a multiplatform approach. RESULTS: HERV-W...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21559469
DOI: 10.1371/journal.pone.0019176
PMCID: PMC3084769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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