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Article

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion

29 Apr 2011

Abstract excerpt

BACKGROUND: Genomic rearrangements involving the ETS family of transcription factors occur in 40-70% of prostate cancer cases. ERG and ETV1 are the most common ETS members observed in these genetic alterations. The high prevalence of these rearrangements and their biological significance represents a novel therapeutic target for the treatment of prostate cancer. METHODS AND FINDINGS: We recently reported the...

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PMID: 21559405
DOI: 10.1371/journal.pone.0019343

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