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Article

Transcriptional Regulation of CXCR4 in Prostate Cancer: Significance of TMPRSS2-ERG Fusions

6 Aug 2013

Abstract excerpt

UNLABELLED: CXCR4 is a chemokine receptor that mediates invasion and metastasis. CXCR4 expression is transcriptionally regulated in cancer cells and is associated with aggressive prostate cancer phenotypes. Previously, we and others have shown that the transcription factor ERG regulates CXCR4 expression in prostate cancer cells and that androgens modulate CXCR4 expression via increasing ERG expression. Herein,...

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PMID: 23918819
DOI: 10.1158/1541-7786.mcr-12-0705

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Transcriptional Regulation of CXCR4 in Prostate Cancer: Significance of TMPRSS2-ERG FusionsPMID 23918819Read ↗

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