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Article

Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.

Neoplasia (New York, N.Y.) - 1 Mar 2007

Mertz Kirsten D, Setlur Sunita R, Dhanasekaran Saravana M, Demichelis Francesca, Perner Sven, Tomlins Scott, Tchinda Joëlle, Laxman Bharathi, Vessella Robert L, Beroukhim Rameen, Lee Charles, Chinnaiyan Arul M, Rubin Mark A

Abstract excerpt

Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this imp...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17401460
DOI: 10.1593/neo.07103
PMCID: PMC1838578

Genes

ERG
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17401460-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.PMID 17401460Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

Pleiotropic Biological Activities of Alternatively Spliced TMPRSS2/ERG Fusion Gene TranscriptsSemantic proximity Read ↗

Distinct genomic aberrations associated with ERG rearranged prostate cancerSemantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Significance of the TMPRSS2:ERG gene fusion in prostate cancer.Semantic proximity Read ↗

Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and ManagementSemantic proximity Read ↗

Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.Semantic proximity Read ↗

Multiple genomic alterations on 21q22 predict various <i>TMPRSS2/ERG</i> fusion transcripts in human prostate cancersSemantic proximity Read ↗

Morphological features of TMPRSS2-ERG gene fusion prostate cancer.Semantic proximity Read ↗

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein with Orthogonal Immunoprecipitation-Mass Spectrometry AssaysSemantic proximity Read ↗

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN LesionsSemantic proximity Read ↗

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