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Article

Insights on the evolution of prolyl 3-hydroxylation sites from comparative analysis of chicken and Xenopus fibrillar collagens.

PloS one - 3 May 2011

Hudson David M, Weis Maryann, Eyre David R

Abstract excerpt

Recessive mutations that prevent 3-hydroxyproline formation in type I collagen have been shown to cause forms of osteogenesis imperfecta. In mammals, all A-clade collagen chains with a GPP sequence at the A1 site (P986), except α1(III), have 3Hyp at residue P986. Available avian, amphibian and reptilian type III collagen sequences from the genomic database (Ensembl) all differ in sequence motif from mammals at...

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Identifiers

PMID: 21559283
DOI: 10.1371/journal.pone.0019336
PMCID: PMC3086908

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Source receipt: pubmed, retrieved 7 Sept 2026.

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