Article
Tag SNP polymorphism of CCL2 and its role in clinical tuberculosis in Han Chinese pediatric population.
PloS one - 4 Feb 2011
Feng Wei-Xing, Mokrousov Igor, Wang Bin-Bin, Nelson Hugh, Jiao Wei-Wei, Wang Jing, Sun Lin, Zhou Si-Rui, Xiao Jing, Gu Yi, Wu Xi-Rong, Ma Xu, Shen Adong
Abstract excerpt
BACKGROUND: Chemokine (C-C motif) ligand 2 CCL2/MCP-1 is among the key signaling molecules of innate immunity; in particular, it is involved in recruitment of mononuclear and other cells in response to infection, including tuberculosis (TB) and is essential for granuloma formation. METHODOLOGY/PRINCIPAL FINDINGS: We identified a tag SNP for the CCL2/MCP-1 gene (rs4586 C/T). In order to understand whether this SNP...
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