Biochemical and molecular analysis of spontaneous and induced mutations at the mouse Mod-1 locus.

doi:10.1016/0165-1161(90)90024-i

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Article

Biochemical and molecular analysis of spontaneous and induced mutations at the mouse Mod-1 locus.

Mutation research - 1 Feb 1990

Cobb R R, Burkhart J G, Dubins J S, Barnett L B, Lewis S E

Abstract excerpt

We have analyzed five Mod-1 (malic enzyme) mutants at the molecular and biochemical level. Four of these mutants, three electrophoretic variants and one null mutant, were induced by ethylnitrosourea (ENU). Another null mutant was the result of a spontaneous mutation. All of these mutations were h...

Topics

Animals
Crosses, Genetic
DNA Restriction Enzymes
Electrophoresis, Starch Gel
Ethylnitrosourea
Gene Expression
Genes
Immunoblotting
Liver
Malate Dehydrogenase
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mutation
RNA, Messenger

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