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Article

A new avian leukosis virus-based packaging cell line that uses two separate transcomplementing helper genomes.

Journal of virology - 1 Mar 1990

Cosset F L, Legras C, Chebloune Y, Savatier P, Thoraval P, Thomas J L, Samarut J, Nigon V M, Verdier G

Abstract excerpt

An avian leukosis virus-based packaging cell line was constructed from the genome of the Rous-associated virus type 1. The gag, pol, and env genes were separated on two different plasmids; the packaging signal and the 3' long terminal repeat were removed. On a plasmid expressing the gag and pol genes, the env gene was replaced by the hygromycin resistance gene. The phleomycin resistance gene was inserted in the...

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Identifiers

PMID: 2154593
DOI: 10.1128/JVI.64.3.1070-1078.1990
PMCID: PMC249219

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