Article
Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer.
International journal of cancer - 1 Apr 2012
Razavi Pedram, Lee Eunjung, Bernstein Leslie, Van Den Berg David, Horn-Ross Pamela L, Ursin Giske
Abstract excerpt
We investigated whether variants in sex steroid hormone metabolism genes modify the effect of hormone therapy (HT) on endometrial cancer risk in postmenopausal non-Hispanic white women. A nested case-control study was conducted within the California Teachers Study (CTS). We genotyped htSNPs in six genes involved in the hormone metabolism in 286 endometrial cancer cases and 488 controls. Odds ratio (OR) and 95%...
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