Article
Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2011
Sombekke M H, van der Voort L F, Kragt J J, Nielsen J M, Guzel H, Visser A, Oudejans C B M, Crusius J B A, Peña A Salvador, Vrenken H, Polman C H, Killestein J
Abstract excerpt
BACKGROUND: The interleukin 7 receptor (IL7R) has been recognized as a susceptibility gene for Multiple Sclerosis (MS). Analysis of rs6897932 (the most strongly MS-associated single nucleotide polymorphism (SNP)), showed effects of genotype on the relative expression of membrane-bound to total amount of IL7R mRNA. OBJECTIVE: We assessed the relevance of IL7R on MS phenotype (including clinical and magnetic...
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