Specific recognition of primer tRNA Lys 3 by HIV-1 nucleocapsid protein: involvement of the zinc fingers and the N-terminal basic extension.

doi:10.1016/s0300-9084(03)00034-8

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Article

Specific recognition of primer tRNA Lys 3 by HIV-1 nucleocapsid protein: involvement of the zinc fingers and the N-terminal basic extension.

Biochimie - 1 May 2003

Tisné Carine, Roques Bernard P, Dardel Frédéric

Abstract excerpt

Reverse transcription of HIV-1 viral RNA uses human tRNA(Lys)(3) as a primer. We have previously characterised the structural aspects of the tRNA(Lys)(3) interaction by NMR. In HIV-1 virions, the nucleocapsid protein NCp7 contains two zinc fingers flanked by basic residues. Using NMR, the respective role of the N-terminal residues and the zinc fingers in the interaction with tRNA(Lys)(3)/NCp7 was investigated by...

Topics

Animals
Capsid Proteins
Gene Products, gag
HIV-1
Humans
Magnetic Resonance Imaging
Mutation
Protein Binding
RNA, Transfer, Lys
Viral Proteins
Virus Replication
Zinc Fingers
gag Gene Products, Human Immunodeficiency Virus

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Open in PubMed

Identifiers

PMID: 12763315
DOI: 10.1016/s0300-9084(03)00034-8

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