Article
Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex.
Journal of neuroimmunology - 1 Jun 2011
Scott Adrian P, Laing Nigel G, Mastaglia Frank, Needham Merrilee, Walter Maggie C, Dalakas Marinos C, Allcock Richard J N
Abstract excerpt
Susceptibility to sporadic inclusion body myositis (sIBM) in Caucasians has been consistently associated with alleles of the major histocompatibility complex (MHC) 8.1 ancestral haplotype (AH) (defined by HLA-B*0801 and HLA-DRB1*0301). In this study recombination mapping was utilised to further refine the known 8.1AH susceptibility region near HLA-DRB1*0301. Caucasian sIBM patients carrying part of the 8.1AH were...
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