Article
Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype.
Neuromuscular disorders : NMD - 1 Nov 2009
Mastaglia Frank L, Needham Merrilee, Scott Adrian, James Ian, Zilko Paul, Day Timothy, Kiers Lynette, Corbett Alastair, Witt Campbell S, Allcock Richard, Laing Nigel, Garlepp Michael, Christiansen Frank T
Abstract excerpt
Susceptibility to sIBM is strongly associated with the HLA-DRB1*03 allele and the 8.1 MHC ancestral haplotype (HLA-A1, B8, DRB1*03) but little is known about the effects of allelic interactions at the DRB1 locus or disease-modifying effects of HLA alleles. HLA-A, B and DRB1 genotyping was perform...
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