Article
E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids.
The European respiratory journal - 1 Nov 2011
Ierodiakonou D, Postma D S, Koppelman G H, Boezen H M, Gerritsen J, Ten Hacken N, Timens W, Vonk J M
Abstract excerpt
E-cadherins form intercellular junctions that maintain epithelial integrity. Epithelial integrity is impaired in asthma and can be restored by inhaled corticosteroids (ICSs). Our aim was to investigate the association of CDH1 gene polymorphisms (single-nucleotide polymorphisms (SNPs)) with airway remodelling, inflammation and forced expiratory volume in 1 s (FEV₁) decline in asthma patients and assess whether...
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