Article
Replication stalling by catalytically impaired Twinkle induces mitochondrial DNA rearrangements in cultured cells.
Mitochondrion - 1 Jul 2011
Pohjoismäki Jaakko L O, Goffart Steffi, Spelbrink Johannes N
Abstract excerpt
Pathological mitochondrial DNA (mtDNA) rearrangements have been proposed to result from repair of double-strand breaks caused by blockage of mitochondrial DNA (mtDNA) replication. As mtDNA deletions are seen only in post-mitotic tissues, it has been suggested that they are selected out in actively dividing cells. By electron microscopy we observed rearranged mtDNA molecules in cultured human cells expressing a...
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