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The Killing of African Trypanosomes by Ethidium Bromide

16 Dec 2010

Abstract excerpt

Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB has long been known to cause loss of the mitochondrial genome, named kinetoplast DNA (kDNA), a giant network of interlocked minicircles and maxicircles. However, the existence of viable parasites lacking kDNA (dyskinetoplastic) led...

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PMID: 21187912
DOI: 10.1371/journal.ppat.1001226

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