Article
A two-mutation model for radon-induced lung tumors in rats.
Radiation research - 1 Jan 1990
Moolgavkar S H, Cross F T, Luebeck G, Dagle G E
Abstract excerpt
The recessive oncogenesis model, according to which inactivation of both alleles of specific genes leads to cancer, has received much recent attention. A mathematical formulation of a two-mutation model for carcinogenesis, which includes the recessive oncogenesis model as a special case, was fitt...
Topics
- Animals
- Bismuth
- Lead
- Lung Neoplasms
- Models, Genetic
- Mutation
- Neoplasms, Radiation-Induced
- Polonium
- Radon
- Radon Daughters
- Rats
- Rats, Inbred Strains