Article
A two-mutation model for radon-induced lung tumors in rats.
Radiation research - 1 Jan 1990
Moolgavkar S H, Cross F T, Luebeck G, Dagle G E
Abstract excerpt
The recessive oncogenesis model, according to which inactivation of both alleles of specific genes leads to cancer, has received much recent attention. A mathematical formulation of a two-mutation model for carcinogenesis, which includes the recessive oncogenesis model as a special case, was fitted to data from a large experimental study in which rats exposed to radon daughters developed malignant lung tumors....
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