Article
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010
Sevenich Lisa, Schurigt Uta, Sachse Kathrin, Gajda Mieczyslaw, Werner Fee, Müller Sebastian, Vasiljeva Olga, Schwinde Anne, Klemm Nicole, Deussing Jan, Peters Christoph, Reinheckel Thomas
Abstract excerpt
The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz in Ctsb (-/-) mice has been suggested. To further define the functional interplay of these proteases in the context of ca...
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